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A Nice Little Cryptography Primer

By itss | 28/06/2021
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Pun Intended.

Category: Technology
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  • The Rarest of All Diseases Are Becoming Treatable
    by msmash on 09/12/2025 at 4:11 pm

    In February, a six-month-old baby named KJ Muldoon became the first person ever to receive a CRISPR gene-editing treatment customized specifically for his unique genetic mutation, a milestone that researchers say marks a turning point in how medicine might approach the thousands of rare diseases that collectively affect 30 million Americans. Muldoon was born with a type of urea-cycle disorder that gives patients roughly a 50% chance of surviving infancy and typically requires a liver transplant; he is now a healthy 1-year-old who recently took his first steps. The treatment's significance extends beyond one child. Scientists at UC Berkeley's Innovative Genomics Institute and the Children's Hospital of Philadelphia are now planning clinical trials that would use Muldoon's therapy as a template, tweaking the molecular "address" in the CRISPR system to target different mutations in other children with urea-cycle disorders. Last month, FDA officials Marty Makary and Vinay Prasad announced a new drug pathway designed to accelerate approvals for such personalized treatments -- a framework inspired in large part by Muldoon's case. Current gene-editing delivery mechanisms limit treatments to disorders in the blood and liver. Many families will still go without bespoke therapies. Read more of this story at Slashdot.

  • 'Colleges Oversold Education. Now They Must Sell Connection'
    by msmash on 09/12/2025 at 3:21 pm

    A tenured USC professor is arguing that universities need to fundamentally rethink their value proposition as AI rapidly closes the gap on human instruction and a loneliness epidemic grips the generation most likely to be sitting in their lecture halls. Eric Anicich, an associate professor at USC's Marshall School of Business, wrote in the Los Angeles Times that nearly three-quarters of 16- to 24-year-olds now report feeling lonely, young adults spend 70% less time with friends in person compared to two decades ago, and a growing majority of Gen Z college graduates say their degree was a "waste of money." Anicich points to a recent Harvard study finding that students using an AI tutor learned more than twice as much as those in traditional active-learning classes, and did so in less time. The implication is stark: if instruction becomes abundant and cheap, colleges must sell what remains scarce -- genuine human community. He notes that his doctoral training included zero coursework on teaching, a norm he says persists across academia. His proposal: fund student life as seriously as research labs, hire professional "experience designers," and treat rituals and collaborative projects as core curriculum rather than amenities. Read more of this story at Slashdot.

  • Microsoft Excel Turns 40, Remains Stubbornly Unkillable
    by msmash on 09/12/2025 at 2:41 pm

    Microsoft Excel, the 40-year-old spreadsheet application that helped establish personal computers as essential workplace tools and contributed to Microsoft's current valuation of nearly $4 trillion, has weathered both the rise of cloud computing and the current AI boom largely unscathed. In its most recent quarter, commercial revenue for Microsoft 365 -- the bundle including Excel, Word, and PowerPoint -- increased 17% year over year, and consumer revenue rose 28%. The software traces its origins to a 1983 Microsoft offsite under the code name Odyssey, where engineers set out to clone Lotus 1-2-3. That program had itself cloned VisiCalc, the first computerized spreadsheet, created by Dan Bricklin for the Apple II in the late 1970s. Bricklin never patented VisiCalc. "Financially it would have been great if we'd have been able to patent it," he told Bloomberg. "And there would be a Bricklin Building at MIT, instead of a Gates Building." Excel now counts an estimated 500 million paying users. The Pentagon pays for 2 million Microsoft 365 licenses. Google's free Sheets product, launched in 2006, captured casual use cases like potluck sign-ups but failed to dislodge Excel from enterprise work. AI chatbots present the latest challenge, but venture capitalists say nearly every AI spreadsheet startup they meet builds on top of Excel rather than replacing it. Read more of this story at Slashdot.

  • India's Aviation Crisis Is All About Too Big to Tame
    by msmash on 09/12/2025 at 2:01 pm

    India's dominant airline IndiGo has cancelled roughly 3,000 flights since last week after new pilot fatigue regulations collided with technical issues and the seasonal schedule shift, stranding more than half a million passengers and forcing aviation authorities to reverse course on the safety rules they had just implemented. InterGlobe Aviation, IndiGo's parent company, told regulators that stricter requirements for night flying and weekly rest periods created an acute crew shortage. The Airline Pilots Association of India called the regulatory rollback a "dangerous precedent," noting that management had known about the requirements since early last year. IndiGo controls 65.6% of India's domestic aviation market as of October 2025 and briefly became the world's most valuable airline in April. The crisis arrives as India's second-largest carrier, Air India, remains under investigation following a June crash that killed 241 passengers and crew. Authorities have imposed temporary price caps to prevent gouging. Read more of this story at Slashdot.

  • Science Journal Retracts Study On Safety of Monsanto's Roundup
    by BeauHD on 09/12/2025 at 1:00 pm

    An anonymous reader quotes a report from the Guardian: The journal Regulatory Toxicology and Pharmacology has formally retracted a sweeping scientific paper published in 2000 that became a key defense for Monsanto's claim that Roundup herbicide and its active ingredient glyphosate don't cause cancer. Martin van den Berg, the journal's editor in chief, said in a note accompanying the retraction that he had taken the step because of "serious ethical concerns regarding the independence and accountability of the authors of this article and the academic integrity of the carcinogenicity studies presented." The paper, titled Safety Evaluation and Risk Assessment of the Herbicide Roundup and Its Active Ingredient, Glyphosate, for Humans, concluded that Monsanto's glyphosate-based weed killers posed no health risks to humans -- no cancer risks, no reproductive risks, no adverse effects on development of endocrine systems in people or animals. Regulators around the world have cited the paper as evidence of the safety of glyphosate herbicides, including the Environmental Protection Agency (EPA) in this assessment (PDF). [...] In explaining the decision to retract the 25-year-old research paper, Van den Berg wrote: "Concerns were raised regarding the authorship of this paper, validity of the research findings in the context of misrepresentation of the contributions by the authors and the study sponsor and potential conflicts of interest of the authors." He noted that the paper's conclusions regarding the carcinogenicity of glyphosate were solely based on unpublished studies from Monsanto, ignoring other outside, published research. "The retraction of this study is a long time coming," said Brent Wisner, one of the lead lawyers in the Roundup litigation and a key player in getting the internal documents revealed to the public. Wisner said the study was the "quintessential example of how companies like Monsanto could fundamentally undermine the peer-review process through ghostwriting, cherrypicking unpublished studies, and biased interpretations." "This garbage ghostwritten study finally got the fate it deserved,â Wisner added. "Hopefully, journals will now be more vigilant in protecting the impartiality of science on which so many people depend." Read more of this story at Slashdot.

  • Evidence That Humans Now Speak In a Chatbot-Influenced Dialect Is Getting Stronger
    by BeauHD on 09/12/2025 at 10:00 am

    Researchers and moderators are increasingly concerned that ChatGPT-style language is bleeding into everyday speech and writing. The topic has been explored in the past but "two new, more anecdotal reports, suggest that our chatbot dialect isn't just something that can be found through close analysis of data," reports Gizmodo. "It might be an obvious, every day fact of life now." Slashdot reader joshuark shares an excerpt from the report: Over on Reddit, according to a new Wired story by Kat Tenbarge, moderators of certain subreddits are complaining about AI posts ruining their online communities. It's not new to observe that AI-armed spammers post low-value engagement bait on social media, but these are spaces like r/AmItheAsshole, r/AmIOverreacting, and r/AmITheDevil, where visitors crave the scintillation or outright titillation of bona fide human misbehavior. If, behind the scenes, there's not really a grieving college student having her tuition cut off for randomly flying off the handle at her stepmom, there's no real fun to be had. The mods in the Wired story explain how they detect AI content, and unfortunately their methods boil down to "It's vibes." But one novel struggle in the war against slop, the mods say, is that not only are human-written posts sometimes rewritten by AI, but mods are concerned that humans are now writing like AI. Humans are becoming flesh and blood AI-text generators, muddying the waters of AI "detection" to the point of total opacity. As "Cassie" an r/AmItheAsshole moderator who only gave Wired her first name put it, "AI is trained off people, and people copy what they see other people doing." In other words, Cassie said, "People become more like AI, and AI becomes more like people." Meanwhile, essayist Sam Kriss just explored the weird way chatbots "write" for the latest issue of the New York Times Magazine, and he discovered along the way that humans have accidentally taken cues from that weirdness. After parsing chatbots' strange tics and tendencies -- such as overusing the word "delve" most likely because it's in a disproportional number of texts from Nigeria, where that word is popular -- Kriss refers to a previously reported trend from over the summer. Members of the U.K. Parliament were accused of using ChatGPT to write their speeches. The thinking goes that ChatGPT-written speeches contained the phrase "I rise to speak," an American phrase, used by American legislators. But Kriss notes that it's not just showing up from time to time. It's being used with downright breathtaking frequency. "On a single day this June, it happened 26 times," he notes. While 26 different MPs using ChatGPT to write speeches is not some scientific impossibility, it's more likely an example of chatbots, "smuggling cultural practices into places they don't belong," to quote Kriss again. So when Kriss points out that when Starbucks locations were closing in September, and signs posted on the doors contained tortured sentences like, "It's your coffeehouse, a place woven into your daily rhythm, where memories were made, and where meaningful connections with our partners grew over the years," one can't state with certainty that this is AI-generated text (although let's be honest: it probably is). Read more of this story at Slashdot.

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